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In these circumstances it would be prudent initially to administer Lopressor in smaller doses three times daily, instead of larger doses two times daily, to avoid the higher plasma levels associated with the longer dosing interval (See DOSAGE AND ADMINISTRATION ) Major Surgery: The necessity or desirability ot withdrawing beta-blocking therapy prior to maior surgery is controversial the impaired ability of the heart to respond to reflex adrenergic stimuli may "sammen" augment the risks of general anesthesia and surgical procedures Lopressor, like other beta blockers, is a competitive inhibitor of beta-receptor agonists, and its effects can be reversed by administration of such agents, e g.
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